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. Author manuscript; available in PMC: 2016 Feb 15.
Published in final edited form as: Blood Cells Mol Dis. 2015 Jul 17;55(4):304–307. doi: 10.1016/j.bcmd.2015.07.010

Figure 1. Regression tree analysis representing the significant predictors of median hepcidin concentrations (IQR) in adult patients with SCD (N=40).

Figure 1

Reticulocyte percent, erythropoietin, ferritin, and hs-CRP are the key variables that predict hepcidin concentration in adult patients with SCD, with reticulocyte percent representing the primary predictor. Higher reticulocyte percent (>4.5%) and erythropoietin (>40 and >80 mIU/ml) predicts lower median hepcidin concentrations, and higher ferritin (>1000 ng/ml) and hs-CRP (>10 mg/L) predicts higher hepcidin median concentrations in this population.

* The lowest median hepcidin concentrations were best predicted by a reticulocyte percent >4.5% and a ferritin <1000 ng/ml (N=8).

** The highest median hepcidin concentrations were best predicted by a reticulocyte percent <4.5% and EPO < 40 mIU/ml (N=5).