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. Author manuscript; available in PMC: 2017 Jan 28.
Published in final edited form as: Cell. 2016 Jan 28;164(3):550–563. doi: 10.1016/j.cell.2015.12.028

Figure 4. A distinct subgroup of IDH-wildtype diffuse glioma with molecular features of pilocytic astrocytoma.

Figure 4

A. Kaplan-Meier survival curves for the IDH-wildtype glioma subtypes. Ticks represent censorship. B. Distribution of previous published DNA methylation subtypes in the validation set, across the TCGA IDH-wildtype specific DNA methylation clusters. C. Distribution of genomic alterations in genes frequently altered in IDH-wildtype glioma. D. Heatmap of TCGA glioma samples ordered according to Figure 2A and two EReg gene signatures defined for the IDH-wildtype DNA methylation clusters. Mean RNA sequencing counts for each gene matched to the promoter of the identified cgID across each cluster are plotted to the right. E. Heatmap of the validation set classified using the random forest method using the 1,300 probes defined in Figure 2A.