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. Author manuscript; available in PMC: 2017 Jan 28.
Published in final edited form as: Cell. 2016 Jan 28;164(3):550–563. doi: 10.1016/j.cell.2015.12.028

Figure 5. Overview of major subtypes of adult diffuse glioma.

Figure 5

Integrative analysis of 1,122 adult glioma resulted in seven different subtypes with distinct biological and clinical characteristics. The groups extend across six DNA methylation subtypes of which the LGm6 cluster was further separated by tumor grade, into PA-like and LGm6-GBM. The size of the circles is proportional to the percentages of samples within each group. DNA methylation plot is a cartoon representation of overall genome-wide epigenetic pattern within glioma subtypes. Survival information is represented as a set of Kaplan-Meier curves, counts of grade, histology and LGG/GBM subtypes within the groups are represented as bar-plots, whereas age is represented as density. Labeling of telomere length and maintenance status is based on the enrichment of samples within each column, similarly for the biomarkers and the validation datasets.