Table 3.
Comparison of LRP burden in limbic stage Dem-AD-LB and PD subjects of the CNDR and BBDP cohorts.
| CNDR Main Clusters
| ||||||
|---|---|---|---|---|---|---|
| Area | Cluster 1 vs. Cluster 2 | Cluster 1 vs. Cluster 3 | Cluster 1 vs. Cluster 4 | Cluster 2 vs. Cluster 3 | Cluster 2 vs. Cluster 4 | Cluster 3 vs. Cluster 4 |
| average rank difference (p-value) | average rank difference (p-value) | average rank difference (p-value) | average rank difference (p-value) | average rank difference (p-value) | average rank difference (p-value) | |
| Medulla | −0.10 (1.0) | 0.41 (<0.0001) | 0.42 (<0.0001) | 0.48 (<0.0001) | 0.49 (<0.0001) | 0.03 (1.0) |
|
| ||||||
| SN | −0.16 (0.028) | 0.48 (<0.0001) | 0.48 (<0.0001) | 0.50 (<0.0001) | 0.50 (<0.0001) | 0.0 (1.0) |
|
| ||||||
| Thalamus | −0.13 (0.48) | 0.25 (<0.0001) | 0.27 (<0.0001) | 0.42 (<0.0001) | 0.44 (<0.0001) | 0.04 (1.0) |
|
| ||||||
| Putamen | −0.21 (0.0001) | 0.33 (<0.0001) | 0.32 (<0.0001) | 0.47 (<0.0001) | 0.46 (0.0001) | 0.0 (1.0) |
|
| ||||||
| Amygdala | −0.22 (<0.0001) | 0.25 (<0.0001) | 0.03 (1.0) | 0.38 (<0.0001) | 0.21 (0.0087) | −0.19 (0.17) |
|
| ||||||
| Cingulate | −0.33 (<0.0001) | 0.43 (<0.0001) | 0.32 (<0.0001) | 0.49 (<0.0001) | 0.47 (<0.0001) | −0.23 (0.0007) |
|
| ||||||
| MTL | −0.25 (<0.0001) | 0.44 (<0.0001) | 0.22 (0.011) | 0.50 (<0.0001) | 0.41 (<0.0001) | −0.44 (<0.0001) |
|
| ||||||
| Middle frontal | −0.39 (<0.0001) | 0.17 (0.0002) | 0.09 (1.0) | 0.4 (<0.0001) | 0.46 (<0.0001) | −0.09 (0.64) |
|
| ||||||
| Parietal | −0.47 (<0.0001) | 0.0 (1.0) | −0.06 (1.0) | 0.48 (<0.0001) | 0.46 (<0.0001) | −0.06 (1.0) |
| CNDR Subclusters
| |||
|---|---|---|---|
| Cluster 2A vs. Cluster 2B | Cluster 2A vs. Cluster 2C | Cluster 2B vs. Cluster 2C | |
| average rank difference (p-value) | average rank difference (p-value) | average rank difference (p-value) | |
| Cingulate | −0.29 (<0.0001) | −0.21 (0.014) | 0.09 (1.0) |
|
| |||
| MTL | −0.34 (<0.0001) | −0.32 (<0.0001) | 0.01 (1.0) |
|
| |||
| Middle frontal | −0.37 (<0.0001) | −0.42 (<0.0001) | 0.07 (1.0) |
|
| |||
| Parietal | −0.41 (<0.0001) | −0.45 (<0.0001) | 0.06 (1.0) |
|
| |||
| Occipital | −0.50 (<0.0001) | 0.00 (1.0) | 0.50 (<0.0001) |
DMN= Dorsal motor nucleus; LC= Locus coeruleus; MTL= Medial temporal lobe (maximum of entorhinal cortex and CA1/Subiculum); SN= Substantia nigra.
Rank difference represents the value of the first comparison group minus the rank of the second group. Therefore positive values indicate a higher burden of LRP in the first group whereas negative values indicate a higher burden of LRP in the second group. All p-values are adjusted for multiple comparisons.