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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Biomaterials. 2016 Jan 6;83:257–268. doi: 10.1016/j.biomaterials.2016.01.021

Figure 1. Stereotaxic System and FUS Set Up.

Figure 1

A. Schematic showing the method of achieving localized BBB opening in a rat model using pulsed ultrasound exposures and intravenous microbubbles. B. A close up view of the brain depicts how microbubbles flowing through the brain vasculature respond to the pressure variation produced by the ultrasound exposures to achieve localized BBB opening. C. The target brain location for all animals in this study is overlaid on the transverse brain atlas slice. D. A corresponding brain slice harvested from an animal exposed to ultrasound shows localized leakage of Evans blue into the corresponding brain region.