Table 3.

Multivariable repeated measures analysis of outcomes. “Estimate” denotes the predicted difference between cet-RT and Chemo-RT groups once other variables in the model are adjusted for. A negative value means chemo-RT worse, a positive value means cet-RT worse.

Repeated Measures	Model 1 (without dose adjustment)			Model 2 (with dose adjustment)
Outcome	Estimate	SE	p value	Estimate	SE	p value
VF−Aspiration	−0.06	0.20	0.78	0.08	0.23	0.72
VF-Penetration	0.50	0.35	0.15	0.57	0.40	0.16
VF-PAS	0.53	0.54	0.33	0.83	0.63	0.19
ORD	0.01	0.16	0.93	0.23	0.18	0.19
XQ-SS	−11.77	5.78	0.04	0.24	6.75	0.97
XQ- FD	−6.38	1.69	<0.01	−3.24	1.93	0.09
XQ- ED	−7.23	2.19	<0.01	−3.59	2.70	0.18
HNQOL-SS	−5.21	3.06	0.09	2.07	3.46	0.55
HNQOL-ED	−5.85	4.50	0.19	2.43	5.23	0.64
UWQOL-SS	−4.78	3.26	0.14	2.59	3.77	0.49
UWQOL-ED	−6.40	4.37	0.14	−3.87	5.43	0.48

Estimates of average difference between treatments groups across time (3 and 12 months) effect without (Model 1) or with (Model 2) adjustment for radiation doses. For VF outcomes, Model 2 adjusts for radiation doses to pharyngeal constrictors, glottis and esophagus. For ORD, Model 2 adjusts for radiation doses to pharyngeal constrictors, glottis and esophagus. For XQ outcomes, Model 2 adjusts for radiation doses to the oral cavity, parotid glands and contralateral submandibular gland. For HNQOL and UWQOL outcomes, Model 2 adjusts for doses to the pharyngeal constrictors, glottis, esophagus, oral cavity, parotid glands and contralateral submandibular gland. Once dose has been adjusted for, there were no significant differences between groups for any outcomes.

ED=eating domain; FD=fasting domain; HNQOL=head & neck quality of life questionnaire; ORD=observer rated dysphagia; PAS=Penetration/Aspiration Score; SS= summary score; UWQOL=University of Washington quality of life questionnaire; VF=videofluoroscopy; XQ= xerostomia questionnaire