Fig. 2.
Hyaluronic acid biosynthetic pathway in S. zooepidemicus. Glucose is first converted by hexokinase to form glucose-6-Phosphate which then enters one of the two distinct pathways to form UDP-glucuronic acid (pgm, hasC and hasB) or UDP-N-acetylglucosamine (hasE, glmS, glmM and hasD). These precursors are then bound together via the action of hyaluronic acid synthase or HAS (encoded by hasA in S. zooepidemicus) to form hyaluronic acid