Table 2.

SF-36 quality of life scores before and during ERT

Clinical outcome measure	Follow-up time intervals (in years)
SF-36 Component summary scores	Pre-ERT Mean sp/y (95 % CI)	0 to 2 years during ERT Mean sp/y (95 % CI)	>2 years during ERT Mean sp/y (95 % CI)
Physical component summary	-0.73 (-1.07; -0.39)**	1.49 (0.76; 2.21)**	-0.15 (-0.43; 0.13)
Mental component summary	0.16 (-0.25; 0.57)	1.03 (-0.07; 2.13)	0.02 (-0.41; 0.46)
SF-36 domain scores
Physical functioning	-1.80 (-2.41; -1.19)**	1.81 (0.38; 3.23)*	0.68 (0.12; 1.25)*
Role physical	-1.20 (-2.92; 0.52)	9.18 (5.83; 12.53)**	2.46 (1.15; 3.77)**
Bodily pain	-2.10 (-3.01; -1.19) **	0.76 (-1.39; 2.92)	-1.96 (-2.95; -0.98)**
General health	0.19 (-0.49; 0.87)	5.22 (3.58; 6.86)**	0.81 (0.13; 1.49)*
Vitality	-0.44 (-1.11; 0.24)	4.10 (2.44; 5.76)**	1.43 (0.77; 2.09)**
Social functioning	-0.74 (-1.66; 0.18)	2.11 (-0.16; 4.39)	0.41 (-0.54; 1.35)
Role emotional	-0.15 (-1.64; 1.34)	3.05 (-1.06; 7.16)	0.19 (-1.15; 1.53)
Mental health	0.13 (-0.60; 0.87)	2.09 (0.57; 3.61)**	0.29 (-0.37; 0.95)
Rotterdam handicap scale score	Pre-ERT Mean sp/y (95 % CI)	During ERT Mean sp/y (95 % CI)
	-0.49 (-0.64;-0.34)**	-0.02 (-0.17; 0.13)

Data shown are mean changes in score points per year (sp/y) as calculated by univariate analysis using mixed model ANOVA

CI confidence interval

*Change is significant at the 0.05 level, **Change is significant at the 0.01 level