. 2015 Apr 1;90(3):701–715. doi: 10.1007/s00204-015-1488-7

Table 3.

Histopathology grades of brown adipose tissue

	Males^a		Females^b
	Grades 1, 2, 3	Grades 4, 5, 6	Grades 1, 2	Grade 3
Control	7	3	4	6
PFOA	4	13	14	4

Grades were defined through a first blinded screening of sections and represent a range of lipid accumulation from no (grade 1), moderate (grade 3), to strong (grade 6) lipid accumulation. In this distribution table, numbers are counts of perinatally control and PFOA-exposed (300 and 3000 µg PFOA/kg body weight/day) individuals with a given grade. Results for both PFOA dose groups were similar, and data have been combined for statistical power

^aThe distribution in the PFOA-exposed males versus control males is statistically significant (p < 0.05) in a two-tailed Fisher’s exact test

^bFor females, the distribution between controls and PFOA-exposed females did not statistically differ but shows a trend (p = 0.097)