(A) Phosphorylation of AMPK and (B) levels of SIRT1 in vehicle (VEH) and 7,8-dihydroxyflavone (7,8-DHF; 5 mg/kg, ip) treated rats, subjected to either sham or fluid percussion injury (FPI). Data are expressed as percentage of Sham/VEH (mean ± SEM). ##P<0.01 vs. Sham/VEH; *P<0.05, **P<0.01 vs. FPI/VEH; ANOVA (two-way) with Bonferroni's comparisons post-hoc test.