Figure 2.

Induction of ventricular tachycardias. Representative ECG recordings of WT (A) and Cap2^gt/+ mice (B). Ventricular extrastimulus pacing close to the refractory period did not lead to the induction of an arrhythmia in WT (S1S2: 50 ms, S2S3: 35 ms). In Cap2^gt/+ the pacing maneuver (S1S2: 50 ms, S2S3: 25 ms) led to the induction of a ventricular tachycardia (VT) lasting over 1200 ms. C – The inducibility of VTs was significantly elevated in the mutant mice compared to WT. D – The number of VT episodes per animal was significantly negatively correlated with the ventricular refractory period (VRP). Mutant mice with longer refractory periods exhibited fewer VT episodes

n = 8–9 per group. *p < 0.05 vs. WT.