Figure 3.

Epicardial mapping. A – Representative epicardial activation maps after applied pacing from the left ventricle. Isochrones are illustrated by black lines, the distance between each line representing 1 ms delay. Accumulation of isochrones as shown in Cap2^gt/+ and Cap2^gt/gt indicates local slowing of conduction. The area of stimulus application is marked with an asterisk. B – Both mutant groups revealed a significant slowing of conduction in longitudinal and transversal myocardial fiber orientation in the left (LV) and right ventricle (RV)

*p < 0.05 compared to WT. WT: n = 4, Cap2^gt/+: n = 4, and Cap2^gt/gt: n = 3.