Table X.

Age specific hazard ratios (95%CI) for all-cause mortality associated with preserved eGFR_cr confirmed versus not confirmed using eGFR_cys

Parameter	< 65 years		65 to 79 years		≥ 80 years		P-valuea
	Preserved eGFRcr not confirmed using eGFRcys	Preserved eGFRcr confirmed using eGFRcys	Preserved eGFRcr not confirmed using eGFRcys	Preserved eGFRcr confirmed using eGFRcys	Preserved eGFRcr not confirmed using eGFRcys	Preserved eGFRcr confirmed using eGFRcys
Deaths/participants	600/13,381		1,237/9,829		376/1,259
Hazard ratio (95% CI):
Model 1	1 (ref)	0.21 (0.17–0.26)	1 (ref)	0.43 (0.37–0.49)	1 (ref)	0.50 (0.40–0.63)	< 0.001
Model 2	1 (ref)	0.32 (0.25–0.41)	1 (ref)	0.57 (0.50–0.66)	1 (ref)	0.54 (0.43–0.69)	< 0.001
Model 3	1 (ref)	0.41 (0.32–0.53)	1 (ref)	0.66 (0.57–0.76)	1 (ref)	0.61 (0.48–0.78)	0.001

95% CI – 95% confidence interval, ACR – albumin: creatinine ratio, CHD – coronary heart disease, eGFR – estimated glomerular filtration rate, hsCRP – high sensibility C-reactive protein.

^aTest for interaction for consistency of hazard ratios across age strata. Preserved eGFR was defined as eGFR ≥ 60 ml/min/1.73 m². Reduced eGFR was defined as eGFR < 60 ml/min/1.73 m². Calculations for eGFR_cr and egFR_cys are shown in Table I. Model 1: Includes adjustment for age, race, gender, region of residence and eGFR_cr. Model 2: Includes adjustments in Model 1 plus adjustment for education level, physical activity, smoking, history of CHD, stroke, diabetes, waist circumference and statin use. Model 3: Includes adjustments in Model 2 plus adjustment for hypertension, serum albumin < 3.8 g/dl, anemia, hsCRP > 3 mg/l and ACR > 30 mg/g.