Figure 1.

Laboratory reports of Mycoplasma pneumoniae infection detection by genomic and serological methods in England and Wales from January 1989 to June 2015. The line at 20 cases per 3 weekly average rolling period defines seven epidemic periods of declining magnitude and clarity, lasting up to 2 years (1991–1992, 1994–1995, 1998–1999, 2001–2003, 2005–2006, 2011, 2015). National reporting categories include antibody detection and antibody-detection rising titre. A rising titre is defined as a four-fold increase in detectable anti-Mycoplasma pneumoniae antibody level.