Figure 1.

Improved pipeline for the construction of the structural brain network. With the inputs of T1-W images, diffusion MRI (dMRI) data, and the automated anatomical labeling (AAL) template and atlas, the brain is parcellated into 90 cortical, and subcortial regions through registrations. Meanwhile, the fiber orientation density function (fODF) of each voxel is estimated by the method of constrained spherical deconvolution (CSD), and a probabilistic whole brain tractography is used to generate the original connectome. Removing the redundant and nonexistent fibers from the original connectome by the linear fascicle evaluation (LiFE) method gives rise to the optimized connectome. Finally the optimized structural brain network is obtained as an adjacency matrix through combining the parcellations and the optimized connectome.