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. 2016 Feb 16;10:12. doi: 10.3389/fncom.2016.00012

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Copyright © 2016 Qi, Meesters, Nicolay, ter Haar Romeny and Ossenblok.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Application to HCP dataset. (A) The fiber length distributions of the original connectome, the optimized connectome with LiFE and the non-optimized connectome without LiFE. (B) The differences between the edges of the optimized and non-optimized networks weighted by various methods in the sparsity range of 0.75–0.95. Left column indicates the number and percentage of significantly different edges as a function of sparsity. Right column indicates the number and percentage of false positive edges as a function of sparsity. (C) Differences of the node strength (NS) between the optimized and non-optimized networks weighted by the fiber number (FN-N). (D) Comparison the global network measures between the optimized and non-optimized networks (the normalized mean characteristic path length, the normalized mean clustering coefficient, and the small-worldness) for the networks weighted by the fiber number (FN-N).