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. 2016 Feb 16;10:12. doi: 10.3389/fncom.2016.00012

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Copyright © 2016 Qi, Meesters, Nicolay, ter Haar Romeny and Ossenblok.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differences of the nodal measures between the optimized and non-optimized networks weighted by the fiber number (FN-N). Here^* indicates there is a significantly difference between the measures from the non-optimized network and the optimized network (p < 0.05). The nodes are ordered according to the nodal measures of the optimized network. The vertical thin and bold lines indicate the mean and mean + SD of the measures of all nodes. (A) The node strength (NS). (B) The node efficiency (NE). (C) The node betweenness centrality (NBC). (D) The nodes with high NBC (>mean + SD; The first row is for the non-optimized network and the second row is for the optimized network).