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Regulation of YAP level and activity during satellite cell differentiation. After activation of quiescent satellite cells (SC), SCs divide and differentiate into myotubes that fuse with existing myofibers or self-renew and return to quiescence. During SC activation, YAP expression increases until this fate decision has been made. In differentiating SCs, YAP is inactivated by increased phosphorylation at Serine 127 (pYAP S127).
