Table 1.
Cell adhesion molecule | Cytoskeleton component (Reference, if the interaction was directly demonstrated) | Direct or proposed linker proteins (Reference where the interaction with the linker protein was shown) |
---|---|---|
NCAM | Spectrin βI (Pollerberg et al., 1986; Leshchyns'ka et al., 2003) | Direct |
Tubulin (Buttner et al., 2003, 2005) | Dynein (Perlson et al., 2013) Kinesin-1 (Wobst et al., 2015) MAP 1A (Buttner et al., 2003) | |
Actin | α-actinin, tropomyosin (Buttner et al., 2003) | |
Fasciclin II | Tubulin | Ankyrin 2 (long isoform; Pielage et al., 2008) |
apCAM | Tubulin | Not shown (Lee and Suter, 2008) |
Actin | Cortactin (Decourt et al., 2009) | |
L1 | Spectrin | Ankyrin B (Garver et al., 1997; Buhusi et al., 2008) |
Actin | Ezrin (Dickson et al., 2002) | |
Tubulin | MAP2 (Poplawski et al., 2012) | |
Neuroglian | Spectrin | Ankyrin (Bouley et al., 2000; Enneking et al., 2013) |
CHL1 | βII spectrin (Tian et al., 2012) | Direct and via ankyrin (Buhusi et al., 2003) |
Actin | Ezrin (Schlatter et al., 2008) | |
Neurofascin | Spectrin | Ankyrin G (Garver et al., 1997; Tuvia et al., 1997; Zhang et al., 1998) |
Actin | Ezrin (Gunn-Moore et al., 2006) | |
NrCAM | Spectrin | Ankyrin (Davis and Bennett, 1994) |
ALCAM | Actin | Syntenin-1, ezrin (Tudor et al., 2014) |
DsCAM | Tubulin | Tubulin folding cofactor D (Okumura et al., 2015) |
nectin | Actin | Afadin (Takahashi et al., 1999) |
SynCAM 1 | Actin | Farp1 (Cheadle and Biederer, 2012) |
Spectrin | Band 4.1-like protein 3, also called 4.1B (Yageta et al., 2002) |
Homologues of mammalian NCAM and L1 and their interaction partners in Drosophila and Aplysia are indicated in dark and light gray, respectively.