Table 1.

Examples of IgSF CAMs, which bind directly or indirectly via linker proteins to the cytoskeleton components.

Cell adhesion molecule	Cytoskeleton component (Reference, if the interaction was directly demonstrated)	Direct or proposed linker proteins (Reference where the interaction with the linker protein was shown)
NCAM	Spectrin βI (Pollerberg et al., 1986; Leshchyns'ka et al., 2003)	Direct
	Tubulin (Buttner et al., 2003, 2005)	Dynein (Perlson et al., 2013) Kinesin-1 (Wobst et al., 2015) MAP 1A (Buttner et al., 2003)
	Actin	α-actinin, tropomyosin (Buttner et al., 2003)
Fasciclin II	Tubulin	Ankyrin 2 (long isoform; Pielage et al., 2008)
apCAM	Tubulin	Not shown (Lee and Suter, 2008)
	Actin	Cortactin (Decourt et al., 2009)
L1	Spectrin	Ankyrin B (Garver et al., 1997; Buhusi et al., 2008)
	Actin	Ezrin (Dickson et al., 2002)
	Tubulin	MAP2 (Poplawski et al., 2012)
Neuroglian	Spectrin	Ankyrin (Bouley et al., 2000; Enneking et al., 2013)
CHL1	βII spectrin (Tian et al., 2012)	Direct and via ankyrin (Buhusi et al., 2003)
	Actin	Ezrin (Schlatter et al., 2008)
Neurofascin	Spectrin	Ankyrin G (Garver et al., 1997; Tuvia et al., 1997; Zhang et al., 1998)
	Actin	Ezrin (Gunn-Moore et al., 2006)
NrCAM	Spectrin	Ankyrin (Davis and Bennett, 1994)
ALCAM	Actin	Syntenin-1, ezrin (Tudor et al., 2014)
DsCAM	Tubulin	Tubulin folding cofactor D (Okumura et al., 2015)
nectin	Actin	Afadin (Takahashi et al., 1999)
SynCAM 1	Actin	Farp1 (Cheadle and Biederer, 2012)
	Spectrin	Band 4.1-like protein 3, also called 4.1B (Yageta et al., 2002)

Homologues of mammalian NCAM and L1 and their interaction partners in Drosophila and Aplysia are indicated in dark and light gray, respectively.