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. 2016 Feb 16;10:9. doi: 10.3389/fnana.2016.00009

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Copyright © 2016 Chen, Zhang, Yushkevich, Liu and Beaulieu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Areas with significant exponential increase of FA and their absolute change per year from age 6 years to age where FA plateaus at its maximum value in 13 tracts. Here, the plateau is defined as 90% of FA of the asymptote of the exponential curve from 6 to 30 years. Faster FA changes were observed in genu of CC, fronto-parietal part of SLF and inferior CST relative to the other areas of the tracts. Smaller tracts such as left ILF, IFO, and CG displayed faster changes in the posterior part of the tracts, though more pronounced in females. Gray regions are those vertices that are either better fitted with a linear model or have no significant correlation with age.