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. 2016 Feb 16;10:9. doi: 10.3389/fnana.2016.00009

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Copyright © 2016 Chen, Zhang, Yushkevich, Liu and Beaulieu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Areas with significant exponential increase of FA and the age needed to reach the maximum plateau value (defined as 90% of maximum) in 13 tracts. Genu of CC, inferior CST, superior portion of SLF, and posterior sections of left ILF and left IFO in females all reach their maximum level before age 15 years. Males have several regions where the maximum level is reached after 20 years, particularly in right CG, right UNC, and left SLF. Gray regions are those vertices that are either better fitted with a linear model or have no significant correlation with age.