Table 2.
Type and Variants of Thyroid Cancer with Associated Preoperative Cytologic Diagnosis
| Primary Bethesda classification | ||||||
|---|---|---|---|---|---|---|
| Type of cancer | AUS (n = 130) | FN (n = 241) | SUSP (n = 411) | Malignant (n = 509) | p for difference | p for trend |
| Papillary carcinoma: | ||||||
| Follicular variant | 92 (71%) | 93 (39%) | 259 (63%) | 104 (20%) | <0.001 | <0.001 |
| Classic variant | 21 (16%) | 46 (19%) | 106 (26%) | 257 (51%) | <0.001 | <0.001 |
| Tall-cell variant | 1 (<1%) | 5 (2%) | 14 (3%) | 59 (12%) | <0.001 | <0.001 |
| Other variantsa | 5 (4%) | 15 (6%) | 19 (5%) | 42 (8%) | 0.086 | 0.056 |
| Follicular carcinoma: | ||||||
| Minimally invasive: | 11 (9%) | 60 (25%) | 4 (1%) | 2 (<1%) | <0.001 | <0.001 |
| Aggressive variantsa | 0 | 7 (3%) | 1 (<1%) | 2 (<1%) | 0.001 | 0.105 |
| Poorly differentiated carcinoma | 0 | 11 (5%) | 4 (1%) | 2 (<1%) | <0.001 | 0.025 |
| Medullary carcinoma | 0 | 2 (<1%) | 1 (<1%) | 11 (2%) | 0.021 | 0.016 |
| Anaplastic carcinoma | 0 | 2 (<1%) | 0 | 8 (2%) | 0.038 | 0.057 |
| Non-thyroid malignancya | 0 | 0 | 2 (<1%) | 17 (3%) | <0.001 | <0.001 |
| Complete histology unavailable | 0 | 0 | 1 (<1%) | 5 (1%) | 0.164 | 0.041 |
a
Complete histopathologic descriptions available in Supplementary Table S2.