Figure 3.

MxA immunohistochemistry on pretreatment tumor biopsies. Low interferon-inducible MxA protein expression on baseline tumor biopsies correlates with improved overall survival after oncolytic adenovirus therapy. Ten patients with available baseline biopsy material were grouped based on MxA protein expression on pretreatment biopsy samples. (a) Staining panels of the biopsies are grouped in columns based on the assessed MxA score. Asterisk indicates strong stromal staining, instead of strong staining at the tumor. Patients C261 and G322 were not involved in the microarray analyses. Patient C261 was a 46-year-old male, who was diagnosed with colorectal cancer. He received treatment with CGTG-401 and had an overall survival of 123 days. Imaging and marker data were not available. Patient G322 was a 49-year-old female. She was diagnosed with gastric cancer and received treatment with CGTG-102. She had an overall survival of 71 days and a progressive disease marker response. Imaging response was not available. (b) Patients with the highest MxA score +3 showed shorter overall survival than with score +1 or +2, which was found borderline significant (P = 0.054). (c) Average DeltaOS in patients with different MxA scores. The P values were not considered significant. Error bars are shown as mean + SEM.