Figure 7.
Recombinant hGCSF does not proliferate tumor cells in vitro and MVhGCSF is not toxic in IfnarKO × CD46 Ge mice permissible to MV infection. (a) Raji and (b) Nalm-6 cells were treated with increasing amounts of rhGCSF and counted every 24 hours by trypan blue exclusion method in vitro. The number of cells/ml is plotted against the time. CD46 transgenic mice were injected intravenously with MV-NSe (N = 5) or MVhGCSF (N = 7). Evaluation was carried out at day 35 after injection. (b) Spleen size in mm. (c) The percentage of NK cells macrophages and neutrophils in the spleens. (d) Serum hGCSF levels in ng/ml.