Figure 1.

Combination therapy of Reovirus with anti-PD-1 antibody. (a) C57BL/6 mice bearing 7 days established s.c. B16 tumors were treated with three doses of i.t. reovirus (7 × 10⁸ pfu/50 μl) or with PBS (days 7, 10, 12). Starting on day 14, mice were treated i.v. with anti-PD-1 antibody (0.25 mg/mouse), or with isotype control IgG (ctl IgG), every other day for eight injections. Survival of tumor-bearing C57BL/6 mice (n = 7 mice per group) is shown. Data are representative of two separate experiments. *P = 0.0084, **P = 0.0005.