Figure 4.

Extended lifespan and improvement in neurological signs in treated AMD cats. (a) The treated AMD cats (n = 6) lived significantly longer than untreated cats (n = 13) and were euthanized at 30–44 weeks of age due to disease progression (log-rank test, P < 0.001). Neurological examinations were performed monthly from treatment to assess the therapeutic effects. (b) The treated cats showed a significantly delayed onset of whole body tremor. (d) Onset of ataxia did not reach statistical significance. (c,e) At 18 weeks of age, both the whole body tremor and truncal ataxia were significantly less severe. Bars represent means ± SEM. *P < 0.05; **P < 0.01. AAV, adeno-associated virus; AMD, alpha-mannosidosis.