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. 2015 Oct 7;14(4):195–203.

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Copyright © 2015 Iranian Neurological Association, and Tehran University of Medical Sciences

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mean of dark neuron (DN) numbers per unit area in the Substintia Nigra pars compacta (SNc) subdivisions of Balb/c mice and its comparison in the different studied groups. The data show that the mean number of DNs per unit area in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) group significantly increased in SNc comparing to L-arginine-Control and Sham-Control Balb/c Mice. Evaluation of neuroprotective effects on DN production in SNc sub-region revealed a significant reduction in the mean number of DNs in L-arginine plus MPTP groups