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Safety and tolerability
| Placebo | Nitrite 80 mg/day | Nitrite 160 mg/day | |
|---|---|---|---|
| Average peak blood methemoglobin, % | 0.68 ± 0.04 | 0.74 ± 0.06 | 1.10 ± 0.06 |
| Peak blood methemoglobin, % | 1.0 | 1.1 | 1.5 |
| Treatment-emergent adverse events, n | |||
| Headache | 1 | 0 | 3 |
| Nausea | 1 | 0 | 0 |
| Fatigue | 0 | 2 | 2 |
| Dizziness/lightheadedness | 1 | 1 | 2 |
| Asymptomatic orthostatic intolerance | 1 | 1 | 1 |
| Dry mouth | 1 | 0 | 0 |
| Subjects with ≥1 adverse events, n | 2 | 4 | 4 |
| Dropouts, n | 1 | 0 | 1 |
Applicable values are means ± SE.
