Table 6.
Placebo |
Nitrite 80 mg/day |
Nitrite 160 mg/day |
||||
---|---|---|---|---|---|---|
Baseline | Week 10 | Baseline | Week 10 | Baseline | Week 10 | |
Carotid systolic pressure, mmHg | 122 ± 6 | 125 ± 4 | 121 ± 7 | 124 ± 8 | 125 ± 4 | 127 ± 7 |
Carotid pulse pressure, mmHg | 56 ± 5 | 59 ± 4 | 57 ± 7 | 60 ± 8 | 60 ± 5 | 63 ± 6 |
Carotid artery diameter at end-diastole, mm† | 6.55 ± 0.16 | 6.59 ± 0.13 | 6.66 ± 0.32 | 6.44 ± 0.33* | 6.58 ± 0.12 | 6.54 ± 0.12 |
Carotid change in diameter, mm† | 0.34 ± 0.03 | 0.34 ± 0.02 | 0.37 ± 0.04 | 0.46 ± 0.06* | 0.40 ± 0.03 | 0.39 ± 0.0.03 |
Carotid augmentation index, % | 25 ± 3 | 19 ± 5 | 20 ± 3 | 18 ± 5 | 19 ± 2 | 17 ± 2 |
Radial augmentation index, % | −10 ± 6 | −10 ± 5 | −11 ± 5 | −11 ± 4 | −13 ± 5 | −17 ± 3 |
Carotid to femoral PWV, cm/s‡ | 782 ± 35 | 774 ± 36 | 780 ± 55 | 845 ± 75 | 946 ± 62 | 942 ± 77 |
Carotid to radial PWV, cm/s | 1062 ± 35 | 1040 ± 30 | 967 ± 27 | 1002 ± 39 | 1014 ± 25 | 1014 ± 34 |
Values are means ± SE.
P < 0.05 vs. group base; †P < 0.05 for time × treatment; ‡placebo (n = 9). PWV, pulse wave velocity.