Table 2. Association results for 11 SNPs in FGF2 with BMI, fat mass and WHRadjBMI in the Chinese discovery sample.
No. | SNP | Physical Position | Genic Position | A1/A2a | MAF | BMI |
Fat Mass |
WHRadjBMI |
β eQTLb | P eQTLb | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
β | P | β | P | β | P | ||||||||
1 | rs1449683 | 123748086 | Exon1 | T/C | 0.165 | −0.255 | 0.061 | −0.877 | 1.11 × 10−4 | −3.03 × 10−3 | 0.261 | −0.059 | 4.86 × 10−3 |
2 | rs308403 | 123757748 | Intron1 | C/T | 0.320 | 0.170 | 0.140 | 0.251 | 0.193 | 1.54 × 10−3 | 0.501 | — | — |
3 | rs308418 | 123768263 | Intron1 | A/G | 0.157 | 0.139 | 0.340 | 0.124 | 0.610 | 5.38 × 10−4 | 0.852 | −0.030 | 0.288 |
4 | rs167428 | 123773439 | Intron1 | C/T | 0.120 | −0.367 | 0.019 | −0.986 | 1.67 × 10−4 | −3.10 × 10−3 | 0.321 | −0.059 | 2.05 × 10−5 |
5 | rs308442 | 123774913 | Intron1 | A/T | 0.305 | −0.202 | 0.107 | −0.724 | 5.20 × 10−4 | −1.21 × 10−3 | 0.625 | −0.065 | 1.40 × 10−6 |
6 | rs3789138 | 123784721 | Intron1 | G/A | 0.500 | −0.127 | 0.212 | −0.377 | 0.027 | 1.66 × 10−3 | 0.412 | 0.070 | 5.09 × 10−6 |
7 | rs308387 | 123786832 | Intron1 | A/G | 0. 043 | −0.115 | 0.651 | −0.299 | 0.482 | −1.03 × 10−2 | 0.041 | — | — |
8 | rs12506710 | 123794127 | Intron1 | C/T | 0.445 | 0.157 | 0.122 | 0.419 | 0.013 | −9.34 × 10−5 | 0.963 | — | — |
9 | rs10011927 | 123798428 | Intron2 | C/T | 0.449 | 0.155 | 0.127 | 0.427 | 0.011 | 5.77 × 10−5 | 0.977 | — | — |
10 | rs1048201 | 123814308 | 3′UTR | T/C | 0.447 | 0.173 | 0.089 | 0.450 | 7.92 × 10−3 | −2.06 × 10−4 | 0.919 | 0.046 | 0.010 |
11 | rs1476217 | 123818511 | 3′UTR | C/A | 0.452 | 0.157 | 0.135 | 0.432 | 0.013 | 3.44 × 10−4 | 0.869 | −0.016 | 0.331 |
Note: MAF, minor allele frequency. β is calculated with respect to the minor allele. Significant P values after multiple testing adjustment (P < 0.0045) are shown in bold.
aA1 represents the minor allele.
bβ eQTL and P eQTL are shown for 210 HapMap unrelated individuals from 4 populations. β eQTL is calculated with respect to the minor allele.