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. 2016 Feb 16;6:21007. doi: 10.1038/srep21007

Figure 2. Late Arc expression contributes to persistence of newly-acquired and reactivated fear memories.

Figure 2

(A) The experimental procedure for (B). (B) (Left) Arc antisense ODN treatment 7 h after conditioning did not affect freezing behavior in the 2 d test (n = 9 mice). (Right) Arc antisense ODN treatment 7 h after conditioning disrupted freezing behavior in the 7 d test (n = 8, 9 mice). (C) The experimental procedure for (D). (D) (Left) Arc antisense ODN treatment 7 h after re-exposure had no effect on freezing behavior in the 2 d test (n = 8 mice). (Right) Arc antisense ODN treatment 7 h after re-exposure impaired freezing behavior in the 7 d test (n = 7 mice). The reminder shock did not affect freezing behavior in a subsequent test. (E) The experimental procedure for (F). (F) Arc antisense ODN treatment in the absence of memory retrieval did not affect freezing behavior in the 7 d test (n = 7 mice). Histological verification of cannula placements are shown in supplementary Fig. S1. **P < 0.01, *P < 0.05.