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. 2016 Feb 16;6:20127. doi: 10.1038/srep20127

Figure 5. Intestinal gluconeogenesis does not impact liver clock, PPARα, LXR, ChREBP, CAR, and PXR activities.

Figure 5

Hepatic mRNA levels of (a) Rev-erbα, Bmal1, Per2, (b) Cyp4a14 and Fgf21, (c) Fasn and Lpk, and (d) Cyp2b10 and Cyp3a11 were measured at ZT6 and ZT18 by real-time quantitative PCR. Data are the mean ± SEM of values measured in wild-type mice (WT) and in mice with intestine-specific deletion of G6Pase (I-G6PcKO) (n = 6 animals/genotype/ZT time point). Statistical analyses were performed with Student’s t-test. In case of unequal variances between the two samples, the Wehch’s two sample t-test was used. P values were corrected for multiple testing using BH procedure and FDR < 5% threshold is considered for significant difference. * represents difference between ZT time points within a genotype; ***FDR < 0.005, **FDR < 0.01, *FDR < 0.05. #represents difference between genotype for a ZT time point; #FDR < 0.05.