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. 2016 Feb 16;6:21248. doi: 10.1038/srep21248

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(A) Sequence alignment of the M4 region of indicated channels. The locations of Glycine hinge are indicated. (B) Exemplar current-time recordings from oocytes expressing the WT TREK-2 channels and G312A in the presence of 100 μM 2-APB. (C) Comparative analysis of the dose-response curves evoked by 2-APB between TREK-2 and G312A.