Figure 4. Functional characterization of the Gly312 hinge in the pHo response of TREK-2 channels.
(A) Exemplar current-voltage recordings from oocytes expressing the WT TREK-2 channels and G312A as pHo transitions among 6.5, 8.0 and 9.3. (B) Concentration-dependence for extracellular alkalization inhibition of TREK-2 and G312A.