Table 1. 2-APB and pH_o response of indicated channels.

Channel	2-APB response		pHoresponse
	ARmaxa	nb	Imin/Imaxc	nb
TREK-2, 5 mM [K+]o	19.46 ± 1.94	7–19	0.22 ± 0.02	13–15
ΔpCt	4.64 ± 0.17	5	0.64 ± 0.02	7
G312A	6.76 ± 0.43	5–6	0.78 ± 0.03	8–9
TREK-2, 0 mM [K+]o	16.72 ± 1.72	5–11	–
TREK-2, 20 mM [K+]o	20.38 ± 1.30	7–12	–
T172S	18.84 ± 1.65	5–11	–
T281S	18.44 ± 1.19	7–11	–
F316A	5.96 ± 1.02	6–7	0.39 ± 0.04	7–8
TREK-1	–		0.20 ± 0.03	7–8
TREK-1ΔpCt	–		0.36 ± 0.02	7
G281A	–		0.14 ± 0.02	6–7
TREK-1mut7	12.40 ± 0.92	5–7	0.18 ± 0.03	6
TREK-1mut7-G281A	4.85 ± 0.60	5–7	0.20 ± 0.01	6

^aThe maximal concentrations of 2-APB used in these curves is 333 μM for these channels, except for ΔpCt (800 μM).

^bThe number of oocytes used for each point in concentration response curves.

^cFor TREK-2, I_min/I_max means I_pH9.3/I_pH6.5; For TREK-1, I_min/I_max means I_pH6.0/I_pH9.3. –Not determined.