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. 2016 Feb 16;6:20987. doi: 10.1038/srep20987

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Copyright © 2016, Macmillan Publishers Limited

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The CDR3 regions of the HC and the LC of the original igL versions (in green) are shown at the top for each gene family. The CDR3 regions of the siblings isolated are shown below with amino acid differences indicated. Sibling igL versions are labelled (i)–(x) (A). A schematic alignment depicting one representative sibling igL version as made is shown (B). Binding curves and fits of sibling igL binding to SEC purified monomeric gp120 by Octet (C). The kD values of the sibling igLs compared to the original igLs are shown (D).