. Author manuscript; available in PMC: 2016 Feb 16.

Published in final edited form as: Clin Genitourin Cancer. 2013 Nov 13;12(3):167–177.e2. doi: 10.1016/j.clgc.2013.11.007

Table 5. Pharmacokinetic Parameters of Sorafenib, Sunitinib, and Sunitinib Metabolite With and Without Trebananib.

	Sorafenib		Sorafenib		Sunitinib		Sunitinib		Sunitinib Metabolite		Sunitinib Metabolite

Trebananib Dose	Without	3 mg/kg	Without	10 mg/kg	Without	3 mg/kg	Without	10 mg/kg	Without	3 mg/kg	Without	10 mg/kg
T_max (hr)^a
Mean	1.1	1.0	1.0	1.0	8.0	8.0	8.1	8.3	8.1	8.0	8.0	8.0
%CV	100	200	37	NA	24	46	35	54	34	39	64	49
C_max (μg/mL)
Mean	0.466	0.507	0.559	0.541	0.0642	0.0703	0.0618	0.0676	0.0212	0.0274	0.0133	0.025
%CV	75.9	40.6	53.2	NA	25.9	20.2	42.9	47.0	88.1	36.5	51.6	37.7
AUC^a (hr·μg/mL)
Mean	2.58	3.18	3.13	3.92	1.30	1.337	1.25	1.41	0.448	0.566	0.268	0.486
%CV	68.1	89.7	12.2	NA	23.4	24.5	40.4	49.6	64.0	34.1	48.1	39.2
CL (μg/mL)
Mean	20.9	173	14.2	78.7	44.8	54.3	46.6	50.7	14.1	20.7	10.5	19.2
%CV	79.6	159	50.7	NA	21.7	24.6	42.1	57.6	70.4	34.4	44.1	44.4

Abbreviations: AUC = Area under the concentration-time curve; C_max = Maximum observed concentration after IV infusion of trebananib; CL = Clearance; CV = coefficient of variation; NA = Not applicable; T_max = Time of maximum concentration after IV infusion of trebananib.

Sorafenib AUC_0-12; sunitinib AUC_0-24.