Table 1.
Selected Baseline Characteristics of the Study Patientsa
| Thiamine (n = 43) | Placebo (n = 45) | |
|---|---|---|
| Demographics | ||
| Age – mean years (SD) | 70 (14) | 65 (17) |
| Sex – no. female (%) | 17 (40) | 19 (42) |
| Race – no. white (%) | 36 (84) | 40 (89) |
| BMIb - kg/m2 (SD) | 29 (9) | 29 (7) |
| Co-morbidities – No. (%) | ||
| Coronary artery disease | 9 (21) | 10 (22) |
| Congestive heart failure | 10 (23) | 12 (27) |
| Hypertension | 24 (56) | 22 (49) |
| Chronic pulmonary disease | 10 (23) | 13 (29) |
| Diabetes | 19 (44) | 6 (13) |
| Insulin-dependent | 5 (12) | 5 (11) |
| Charlson Comorbidity Indexc – median (quartiles) | 2 (1, 3) | 3 (1, 5) |
| Lactate values | ||
| Lactate – median mmol/L (quartiles) | 4.1 (2.9, 5.0) | 4.1 (3.1, 6.4) |
| Lactate > 4 mmol/L – no. (%) | 26 (60) | 24 (53) |
| Laboratory values at enrollmentd – median (quartiles) | ||
| White blood count (×103) | 13.9 (8.7, 22.5) | 13.1 (4.6, 19.3) |
| Hemoglobin (g/dL) | 10.0 (8.9, 13.0) | 10.4 (9.3, 12.5) |
| Creatinine (mg/dL) | 1.8 (1.0, 2.6) | 1.9 (1.4, 3.0) |
| Glucose (mg/dL) | 145 (91, 191) | 136 (116, 191) |
| Mechanical ventilation and severity of illness | ||
| Mechanical ventilation at time of enrollment – no (%) | 31 (74) | 30 (67) |
| APACHE II score at enrollment – mean (SD) | 25.7 (9.1) | 26.5 (9.2) |
| SOFA score at enrollment – mean (SD) | 10.1 (3.7) | 10.2 (3.7) |
a
SD denotes standard deviation, BMI: body mass index, APACHE II: Acute Physiology and Chronic Health Evaluation II, SOFA: Sequential Organ Failure Assessment score
b
Data missing on 5 patients
c
Data missing on 8 patients
d
Data missing on 6 to 9 patients