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Aβ1–42 -induced bilateral ChAT neuronal (A) and fiber (B) loss in estren treated mice compared to control groups. Estren treatment successfully rescued reaching performance on the single pellet retrieval task (C) and novel object recognition (D) in Aβ1–42 –lesioned mice. Histograms show mean ± SEM (n = 10). *P < 0.05; **P < 0.01; ***P < 0.001 (ANOVA (A) and repeated-measures ANOVA (B) with post hoc Bonferroni test).
