Table 2. The enriched Gene Ontology (GO) terms in molecular function (MF), biological process (BP) and cellular component (CC) categories for target genes of all the 13 differentially expressed miRNAs.

GO_ID	GO_term	Category	Count	Target Genes	FDR
GO:0005515	Protein binding	MF	433	FZD1, FZD3, IGF1R, CBL, CREBBP, FOXO3, SMAD3, SMAD5, RB1, SALL1, SOX2, SOX4, TFAP2B, WT1, CREB5	0.000126268
GO:0004930	G-protein coupled receptor activity	MF	11	FZD2, LPAR4, GPR34, FZD3, FZD1, GPR64, GPR75, GPR126, ELTD1, GPR115, TAS2R20	0.000125237
GO:0003700	Sequence-specific DNA binding transcription factor activity	MF	100	CBL, CREBBP, CREM, ELK4, FOXO3, GABPB1, SMAD3, SMAD5, SMAD7, PROX1, RB1, SALL1, SOX2, SOX4,TFAP2B,WT1, CREB5…	0.001452774
GO:0001105	RNA polymerase II transcription coactivator activity	MF	8	CREBBP, POU3F1, SOX4, SOX11, TFAP2B, CITED2, ANKRD1, HIPK2	0.049058312
GO:0045893	Positive regulation of transcription, DNA-dependent	BP	61	FZD1, FZD2, CREBBP, SMAD3, SMAD5, NFYB, PROX1, RB1, RNF4, SALL1, SOX2, SOX4, SOX9, HNF1B, TFAP2B, WT1, CREB5, CITED2	0.004632587
GO:0006351	Transcription, DNA-dependent	BP	170	CREM, ELK4, GABPB1, GATA2, HIC1, HOXA5, JUND, SMAD3, SMAD5, SMAD7, MTF1, NFYB, PBX1, RB1, RNF4, SALL1, SOX2	0.004014426
GO:0045944	Positive regulation of transcription from RNA polymerase II promoter	BP	77	JUND, SMAD3, SMAD5, SMAD7, MTF1, PBX1, PROX1, RB1, RNF4, SALL1, SOX2, SOX4, SOX9, HNF1B, TFAP2B,	0.006415167
GO:0007156	Homophilic cell adhesion	BP	25	CDH2, CDH10, DSC2, PCDH7, ROBO2, MPZL2, NPTN, PCDH11X, CDH20, PCDH18	0.008450129
GO:0005634	Nucleus	CC	396	CBL, CREBBP, SMAD3, SMAD5, RB1, RNF4, SALL1, SOX2, SOX9, HNF1B, ZEB1, TFAP2B, WT1, CREB5,	0.00852864
GO:0005576	Extracellular region	CC	56	ADM, ANGPT2, COL1A2, EREG, FBN1, IGF1, IGSF1, KITLG, NOTCH3, YBX1, LRP8, ADAM12, NRP1, CD200R1	0.009038887
GO:0005883	Neurofilament	CC	6	NEFM, NEFH, NEFL, NRP1, INA, DLGAP2	0.017283848

FDR: false discovery rate.