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. 2016 Feb 16;6:21262. doi: 10.1038/srep21262

Figure 8. DDR1 antisense treatment alleviated renal histological damages and inflammation induced by UUO.

Figure 8

(A) Representative views of Masson’s trichrome coloration on renal sections at day 7 in Sham, UUO + Scr and UUO + As mice (scale bar = 50μm). Right: Estimation of tubular dilation at day 7. n = 4–12. **p < 0.01, and ***p < 0.001 vs Control; #p < 0.05, vs UUO + Scrambled. (B) Representative views of Sirius Red coloration on renal sections at day 7 in Sham, UUO + Scr and UUO + As mice showing accumulation of interstitial fibrillar collagen (scale bar = 50μm). Right: Quantification of fibrillar collagen. n = 4–12. *p < 0.05 and ***p < 0.001 vs Control; ##p < 0.01 vs UUO + Scrambled. (C) Representative examples of F4/80 immunostaining on renal sections in Sham, UUO + Scr and UUO + As mice showing the presence of macrophages in renal interstitium (scale bar = 50μm). Right: Evaluation of the percentage of positive area for F4/80 staining. n = 4–12. *p < 0.05, and ***p < 0.001 vs Control; #p < 0.05 vs UUO + Scrambled.