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. 2016 Feb 16;6:20960. doi: 10.1038/srep20960

Figure 11. Blockade of orexinergic receptor-1 in the cerebellum disrupted both mPFC- cerebellum theta-band coherence and adaptive CR performance.

Figure 11

(A,B): Injections of SB-334867 into the intermediate cerebellum decreased mPFC-cerebellum coherence in theta-band (5.0–12.0 Hz) instead of in the delta-band (0.5–4.5 Hz). (C) Relative theta power in the cerebellum was not significantly attenuated by the SB-334867 injections. (D) Compared with DMSO (n = 7, red circles), the SB-334867 injections (n = 7, blue triangles) decreased the latency to CR peak in the early learning stage (ELS, days 2–4). (E,F) The SB-334867 injections seemed not to reduce the incidence and magnitude of trace CRs. Data are shown as mean ± SEM. Symbols are the same for (A–F). The averaged effects of SB-334867 (black traces) and DMSO (gray traces) injections on the CR performance on days 4 and 8 are illustrated, respectively.