Figure 1. Antimalarial drug responses of Plasmodium falciparum C2A infected Aotus monkeys.
(A) Parasitemia response plots of Aotus monkeys infected with the P. falciparum C2A clone passage X. Animals were inoculated with 5 × 106 infected red blood cells from a donor monkey (MN26006, passage IX) and treated when parasitemia reached >105 parasites × μL of blood. Panel (A) shows group 1 animals treated with MQ at 40 mg/Kg orally once, group 2 animals treated with AS at 33 mg/Kg orally × three days and group 3 animals treated with MQ and AS at 33 mg/Kg × three days and MQ at 40 mg/Kg orally once. Panel (B) shows a spleen intact control treated with AS at 33 mg/Kg × three days +MQ at 40 mg/Kg orally once on day 16 of infection. Panel (C) shows parasitemia responses of MN24058 and MN26008 inoculated with PfC2A passages III and IV respectively and treated with AS at 33 mg/Kg × three days i.v. +MQ at 40 mg/Kg orally once.