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. Author manuscript; available in PMC: 2016 Feb 16.
Published in final edited form as: Nature. 2015 Jul 23;523(7561):468–471. doi: 10.1038/nature14569

Figure 1. Zebrafish whole kidney marrow (WKM) competitive transplantation-based chemical screen identifies EETs as enhancers of marrow engraftment.

Figure 1

a, Schematic of zebrafish WKM competitive transplantation. b, Calculation of relative engraftment capability (G/R). White dashed line: kidney; Gkid/Rkid, kidney fluorescence intensity; Gbkg/Rbkg, background fluorescence intensity. c, The G/R ratios from imaging linearly correlated with flow cytometry analysis of the same recipients (linear regression). wpt, weeks post transplant. d, Serial dilution competitive transplantation with varying donor GFP:DsRed2 ratios. e, 4 hr transient chemical treatment increased WKM engraftment. 11,12- and 14,15-EET, 0.5 μM. Unpaired two-tailed t-test, mean with s.e.m. (d–e).