. Author manuscript; available in PMC: 2017 Feb 1.

Published in final edited form as: DNA Repair (Amst). 2015 Dec 4;38:140–146. doi: 10.1016/j.dnarep.2015.11.015

Table 2.

Conditional MMR knockout mouse lines.

Gene	Cre-Transgene	Target Tissue	Observed Phenotype	MSI	Ref.
Msh2^loxP	Villin-Cre	Small and large intestine	Small intestinal tumors	+++	25
Msh2^loxP	Ella-Cre	All tissues	T-cell lymphomas Small intestinal tumors	na	25
Msh2^loxP	Lgr5-CreERT2	Lgr5 expressing stem cells	Small intestinal tumors	na	50
Msh2^loxP	Adenoviral-Cre	Cre encoding adenovirus	Large intestinal tumors in combination with Apc^loxP allele	na	48
Msh2^loxP	D9-Cre	Medium-spiny GABA-ergic projection neurons (MSNs)	Reduced HTT-CAG expansions and modified huntingtin phenotypes	na	54
Mlh1^loxP	Ella-Cre	All tissues	T-cell lymphomas Gastrointestinal tumors	+++	55
Mlh1^loxP	Lck-Cre	Lck expressing early stage thymocytes	T-cell lymphomas	++	55