Table 2.
Cardiac magnetic resonance indices of left ventricular structure and function, stratified by obesity status and presence of weight loss from Exam 1 to Exam 5. Values presented at median and interquartile range.
| Variable | Weight loss (N=639) | Weight stable (N=1201) | Weight gain (N=511) | P |
|---|---|---|---|---|
| LV ejection fraction (Exam 1) (%) | 64.0 (60.1, 67.1) | 63.4 (59.6, 66.7) | 62.6 (58.8, 65.8) | 0.0003 |
| %ΔLV ejection fraction | −0.7 (−8.1, 6.5) | −0.9 (−7.4, 7.9) | 0.6 (−6.5, 8.5) | 0.04 |
| Raw (un-indexed) LV parameters | ||||
| LV mass (Exam 1) (g) | 116.4 (100.2, 134.6) | 113.5 (97.1, 134.7) | 113.1 (96.2, 134.2) | 0.07 |
| Δ LV mass (Exam 1 to 5) | −2.7 (−12.9, 7.8) | 1.9 (−7.8, 12.4) | 4.4 (−6.6, 15.3) | <0.0001 |
| %Δ LV mass (Exam 1 to 5) | −2.3 (−11, 6) | 1.8 (−7, 11) | 4.1 (−5.9, 13.8) | <0.0001 |
| LV end-diastolic volume (Exam 1) (ml) | 124.8 (108.8, 145.3) | 125.8 (108.9, 147.6) | 125.8 (107.8, 146.6) | 0.51 |
| %Δ LV end-diastolic volume (Exam 1 to 5) | −9.9 (−19, 0.3) | −8.6 (−18.7, 0.6) | −7.2 (−16, 3) | 0.05 |
| Height-indexed LV parameters | ||||
| Indexed LV mass (Exam 1) (g/m2.7) | 29.9 (26.4, 33.7) | 28.7 (25.6, 32.3) | 28.9 (25.6, 32.3) | <0.0001 |
| %Δ LV mass index (Exam 1 to 5) | 0.4 (−8.5, 10.5) | 3.8 (−5.0, 13.6) | 5.4 (−3.5, 16.0) | <0.0001 |
| LV end-diastolic volume (Exam 1) (ml/m2.7) | 32.2 (28.3, 36.1) | 32.1 (28.2, 35.6) | 32.3 (28.8, 35.6) | 0.76 |
| %Δ LV end-diastolic volume (Exam 1 to 5) | −7.3 (−16.2, 3.3) | −6.6 (−16.4, 2.8) | −5.3 (−14.5, 4.7) | 0.37 |
| LV mass to volume ratio (Exam 1) | 0.94 (0.84, 1.05) | 0.90 (0.81, 1.00) | 0.89 (0.81, 0.99) | <0.0001 |
| %Δ LV mass to volume ratio (Exam 1 to 5) | 7.4 (−4.1, 21.2) | 11.0 (−0.4, 26.6) | 12.2 (−0.4, 26.9) | 0.0001 |