Table 2.

Group differences in brain activation in whole-brain analyses, family-wise error corrected p < 0.05

Contrast	Hemisphere	Z score	Peak coordinates MNI (mm)			Cluster size (voxel)	Brain region
			x	y	z
Stopping
Controls > OCD
OCD > Controls	L	4.94	−24	−54	22	4	Cuneus
	R	5.20	30	4	32	3	Precentral gyrus
	L	4.77*	−16	6	26	2	Caudate
Shifting
Controls > OCD	L	5.54	−24	−48	−16	15	Fusiform
	R	5.39	48	−74	10	12	Middle temporal
	R	5.33	30	−72	24	17	Middle occipital
	L	5.10	−6	−80	−4	8	Lingual
	L	5.01	−36	−82	−4	6	Middle occipital
	L	4.97	−2	16	50	6	Pre-supplementary motor area
	R	5.00	14	−6	−6	3	Thalamus
	L	4.99	−4	10	60	1	Supplementary motor area
	L	4.87	−30	−78	36	1	Middle occipital
	L	4.84	−26	52	18	1	Middle frontal
	R	4.83	38	−44	−12	1	Fusiform
	R	4.81	26	−58	20	1	Precuneus
	R	4.79	36	−78	18	1	Middle occipital
Interaction a
OCD > Controls	L	5.48	0	−4	8	70	Thalamus
	L	5.37	−12	−6	16		Caudate
	R	5.28	18	−10	−6	7	Thalamus
	R	4.98	12	−4	16	6	Caudate
	L	4.97	−36	−16	30	4	Postcentral gyrus
	R	4.89	40	−56	8	4	Middle temporal gyrus
	R	4.84	28	−58	22	3	Precuneus
	R	4.82	4	−10	12	3	Thalamus
	R	4.81	14	4	32	1	Anterior cingulate
	R	4.72	10	−58	50	1	Precuneus

OCD, Obsessive compulsive disorder; MNI, Montreal Neurological Institute.

Coordinates are in MNI space. All differences are at whole-brain with family-wise error corrected at p < 0.05 unless otherwise stated.

^aInteraction refers to voxels associated with greater activation in OCD patients compared to controls when stopping but reduced activation in OCD patients compared to controls when shifting.

*Significant at p < 0.06 corrected for family-wise error.