Table 1.
Distribution of the polymorphisms in IL-1A, IL4, NFKB1 and PAR1 genes in Brazilian regions and parental populations
| Genotypes | North No. (%) |
Northeast No. (%) |
Midwest No. (%) |
Southeast No. (%) |
South No. (%) |
Native Americans No. (%) |
Africans No. (%) |
Europeans No. (%) |
|---|---|---|---|---|---|---|---|---|
| IL1A (rs3783553) |
180 | 187 | 186 | 184 | 191 | 222 | 211 | 268 |
| Ins/Ins | 52 (28.9) | 89 (47.6) | 57 (30.6) | 91 (49.5) | 102 (53.4) | 08 (13.5) | 129 (61.1) | 132 (33.7) |
| Ins/Del | 92 (51.1) | 77 (41.2) | 100 (53.8) | 74 (40.2) | 70 (36.6) | 65 (45.5) | 71 (33.7) | 111 (55.9) |
| Del/Del | 36 (20.0) | 21 (11.2) | 29 (15.6) | 19 (10.3) | 19 (10.0) | 149 (41.0) | 11 (5.2) | 25 (10.4) |
| Ins | 0.545 | 0.682 | 0.575 | 0.696 | 0.717 | 0.182 | 0.780 | 0.700 |
| Del | 0.455 | 0.318 | 0.425 | 0.304 | 0.283 | 0.818 | 0.220 | 0.300 |
| IL4 (rs79071878) |
180 | 187 | 186 | 184 | 191 | 222 | 211 | 268 |
| A3/A3 | 61 (33.9) | 109 (58.3) | 104 (55.9) | 98 (53.3) | 114 (60.0) | 12 (5.4) | 22 (10.4) | 143 (53.3) |
| A3/A2 | 89 (49.4) | 72 (38.5) | 70 (37.6) | 78 (42.4) | 69 (36.3) | 77 (34.7) | 133 (63.0) | 109 (40.7) |
| A2/A2 | 30 (16.7) | 06 (3.2) | 12 (6.5) | 08 (4.3) | 07 (3.7) | 133 (59.9) | 56 (26.6) | 16 (6.0) |
| A3 | 0.586 | 0.775 | 0.747 | 0.745 | 0.782 | 0.227 | 0.420 | 0.737 |
| A2 | 0.414 | 0.225 | 0.253 | 0.255 | 0.218 | 0.773 | 0.580 | 0.263 |
| NFKB1 (rs28362491) |
180 | 187 | 185 | 184 | 191 | 222 | 211 | 268 |
| Ins/Ins | 34 (18.9) | 75 (40.0) | 62 (33.5) | 61 (33.2) | 73 (38.2) | 30 (13.5) | 47 (22.3) | 90 (33.6) |
| Ins/Del | 99 (55.0) | 80 (43.0) | 88 (47.6) | 88 (47.8) | 93 (48.7) | 101 (45.5) | 109 (51.7) | 151 (56.3) |
| Del/Del | 47 (26.1) | 32 (17.0) | 35 (18.9) | 35 (19.0) | 25 (13.1) | 91 (41.0) | 55 (26.0) | 27 (10.1) |
| Ins | 0.464 | 0.615 | 0.573 | 0.571 | 0.626 | 0.363 | 0.481 | 0.617 |
| Del | 0.536 | 0.385 | 0.427 | 0.429 | 0.374 | 0.637 | 0.519 | 0.383 |
| PAR1 (rs11267092) |
180 | 187 | 186 | 183 | 191 | 222 | 199 | 267 |
| Ins/Ins | 11 (6.1) | 17 (9.1) | 18 (9.8) | 22 (12.0) | 16 (8.4) | 02 (0.9) | 56 (28.1) | 12 (4.5) |
| Ins/Del | 56 (31.1) | 76 (40.6) | 67 (36.0) | 64 (35.0) | 61 (31.9) | 17 (7.7) | 86 (43.2) | 98 (36.7) |
| Del/Del | 113 (62.8) | 94 (50.3) | 101 (54.3) | 97 (53.0) | 114 (59.7) | 203 (91.4) | 57 (28.7) | 157 (58.8) |
| Ins | 0.217 | 0.294 | 0.277 | 0.295 | 0.243 | 0.047 | 0.497 | 0.228 |
| Del | 0.783 | 0.706 | 0.723 | 0.705 | 0.757 | 0.953 | 0.503 | 0.772 |