Table 1.
miR-34a expressiond | miR-34a promoter methylation | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
n. (%) | Missing | Median | p-valueb | n. (%) | Missing | Negative | Positive | p-valuec | ||||
Presence of disease | healthy samples | 8 | 5,7 % | 0 | 1,39 | 8 | 5,7 % | 8 | - | - | ||
cancers | 133 | 94,3 % | 38 | 0,39 | 0.002 f | 133 | 94,3 % | 37 | 61 | 34 | - | |
Age | <62.3 yearsa | 66 | 49,6 % | 16 | 0,44 | 66 | 49,6 % | 19 | 30 | 17 | ||
>62.3 years | 67 | 50,4 % | 22 | 0,33 | 0.136 | 67 | 50,4 % | 18 | 31 | 17 | 0.939 | |
Histotype | serous | 67 | 50,4 % | 22 | 0,33 | 67 | 50,4 % | 14 | 32 | 21 | ||
endometrioid | 24 | 18,0 % | 6 | 0,5 | 24 | 18,0 % | 6 | 12 | 5 | |||
mucinous | 37 | 27,8 % | 10 | 0,4 | 37 | 27,8 % | 15 | 15 | 7 | |||
clear cell | 5 | 3,8 % | 0 | 1,07 | 0.215 | 5 | 3,8 % | 2 | 2 | 1 | 0.799 | |
FIGO stage | early stages (I-II) | 31 | 23,3 % | 9 | 0,4 | 31 | 23,3 % | 10 | 15 | 6 | ||
late stages (III-IV) | 102 | 76,7 % | 29 | 0,36 | 0.192 | 102 | 76,7 % | 27 | 46 | 28 | 0.434 | |
Grading | 1 | 4 | 3,0 % | 1 | 1,43 | 4 | 3,0 % | 0 | 4 | 0 | ||
2 | 74 | 55,6 % | 23 | 0,44 | 74 | 55,6 % | 21 | 37 | 15 | |||
3 | 55 | 41,4 % | 14 | 0,33 | 0.028 e | 55 | 41,4 % | 16 | 20 | 19 | 0,046e | |
Residual disease | RD = 0 | 49 | 37,1 % | 9 | 0,42 | 49 | 37,1 % | 19 | 23 | 7 | ||
RD > 0 | 83 | 62,9 % | 29 | 0,36 | 0.491 | 83 | 62,9 % | 17 | 38 | 27 | 0,085 | |
Type | type 1 | 91 | 68,4 % | 26 | 0,43 | 91 | 68,4 % | 28 | 45 | 17 | ||
type 2 | 42 | 31,6 % | 12 | 0,28 | 0.037 e | 42 | 31,6 % | 9 | 16 | 17 | 0,020 e | |
Serous | LGSC | 13 | 29,5 % | 6 | 0,77 | 13 | 29,5 % | 2 | 8 | 3 | ||
HGSC | 31 | 70,5 % | 12 | 0,21 | 0.004 f | 31 | 70,5 % | 7 | 12 | 12 | 0,207 | |
p53 mutation | no | 30 | 33,0 % | 12 | 0,7 | 30 | 33,0 % | 6 | 18 | 6 | ||
yes | 61 | 67,0 % | 19 | 0,33 | 0.003 f | 61 | 67,0 % | 18 | 22 | 20 | 0,07 |
aMedian value in cancer cohort. bMann–Whitney test or Kruskal-Wallis test cchi-square test. dArbitrary units normalized to TBP. eSignificant at the 0.05 level (2-tailed). fSignificant at the 0.01 level (2-tailed)